What is ex vivo biodistribution?

Ex vivo biodistribution measures the amount of radiopharmaceutical accumulated in harvested tissues at specific time points. Results are expressed as percent injected dose per gram (%ID/g) or standardized uptake values (SUV), providing quantitative data on tissue-level targeting and clearance.

How many time points are recommended for biodistribution studies?

Typically 4-6 time points are recommended to capture the full pharmacokinetic profile, from early distribution (1-4 hours) through clearance (24-72+ hours). The optimal schedule depends on your compound's expected half-life and target kinetics.

What tissues do you routinely collect?

Standard tissue panels include blood, heart, lungs, liver, spleen, kidneys, stomach, intestines, muscle, bone, brain, and tumor. Additional tissues like pancreas, adrenals, or specific lymph nodes can be added based on your target expression profile.

What is autoradiography and when is it useful?

Autoradiography provides high-resolution spatial mapping of radioactivity distribution within tissues. It's particularly valuable for visualizing heterogeneous uptake within tumors, confirming target localization, and assessing micrometastases that may be missed by gamma counting alone.

Ex Vivo

Gain detailed insights into where your radiopharmaceutical goes and how long it stays. Our ex vivo biodistribution studies provide the quantitative data essential for dosimetry and understanding tissue-level targeting.

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What We Offer

Ex Vivo Capabilities

Comprehensive tissue analysis providing quantitative biodistribution data essential for dosimetry and regulatory submissions.

Analytical Services

Ex Vivo Analytical Portfolio

Comprehensive analytical capabilities for tissue-level characterization, from biodistribution quantification to molecular analysis and sample preservation.

Complete Blood Count (CBC)Comprehensive Metabolic PanelPlasma/Serum Stability+1 more

iQID AutoradiographyPhosphor ImagingWhole-Body Autoradiography

Flow CytometryImmunohistochemistryImmunocytochemistry+2 more

FFPE ProcessingOCT EmbeddingFresh Frozen

Complete Biodistribution Studies: Our "Cut and Count" studies harvest tumors and up to 20 organs per animal at multiple time points, providing %IA/g and SUV values, and time-activity curves essential for dosimetry calculations and IND submissions.